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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Parameter Optimization for The Production of L-asparaginase by Response Surface Methodology by Beauveria bassiana SS18/41.

Author: UPLOADED BY-ADMIN, P.V. KAMALA KUMARI, G.GIRIJA SANKAR, T.PRABHAKAR
Abstract: A Central composite Design of Response Surface Methodology was used to identify the interactive effect of the four variables dextrose, L-asparagine, pH and inoculum level on the production of L-asparaginase from Beauveria bassiana SS18/41. Using Response Surface Methodology (RSM) it was found that a medium containing 0.43%w/v of dextrose, 1.1% w/v of L-asparagine and pH of 7.5 of L-asparagine was optimum for production of L-asparaginase. The maximum experimental response for L-asparaginase production was 19.64 IU/mL whereas the predicted value was 19.31 IU/mL indicating a strong agreement between them. The model was also validated by repeating the experiments under the optimized conditions using shake flask fermentation that resulted in L-asparaginase production of 19.88 IU/mL (predicted response 19.90 IU/mL) that was obviously in close relation with the model prediction. The experimental values were found to be very close to the predicted values and hence the model was successfully validated.
Keyword: Beauveria bassiana, SS18/41, submerged fermentation, L-asparaginase, CCD
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0.12
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