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Investigation of Immunomodulatory Potential of Abutilon indicum Linn. Leaves
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UPLOADED BY-ADMIN, SWITI B. GAIKWAD, G. KRISHNA MOHAN
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| Abstract:
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Abutilon indicum Linn. (Sweet) is a hairy herb commonly known as ‘Indian Mallow’ belonging to family Malvaceae. The
assessment of immunomodulatory activity of Petroleum ether (PEA), Chloroform (CHA), and Methanol (MEA) extracts
(100, 200, 400 mg/kg b.w, p.o) of Abutilon indicum leaves were carried out by Delayed type hypersensitivity (DTH) for
cellular immunity, Haemagglutination antibody (HA) titre for humoral immunity, Cyclophosphamide induced
myelosuppression, and T cell population in male wistar albino rats. Sheep red blood cells (SRBC) were used as an antigen.
Levamisole and Cyclophosphamide were used as standard drugs for immunomodulation and immunosuppression
respectively. Increase in DTH response of animals revealed the stimulatory effect of methanol extract (p<0.01) on T
lymphocytes i.e cell mediated immunity or specific immunity. Increasing doses of methanol extract has shown higher HA
titre value (p<0.05). Methanol extract at all doses has shown restoration of WBC count, but increasing doses of extract has
not showed much restoration of haematological parameters. All the extracts have shown increased lymphocyte and E-rosette
formation when compared to control group. Results of the present study suggest that methanolic extract of the A. indicum
leaves possess significant immunostimulatory effect on both cellular and humoral immunity.
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Immunomodulatory, Abutilon indicum, Malvaceae, DTH, HA titre, Myelosuppression, T cells
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| DOI:
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