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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation Development and Evaluation of SEDDS of Poorly Soluble Drug Made by Novel Application of Mixed Solvency Concept

Author: UPLOADED BY-ADMIN, MAHESHWARI R. K., PATEL S. K.
Abstract: Self-emulsifying formulations are the isotropic mixtures of oil, surfactant and co-surfactant which under conditions of gentle agitation form fine emulsion. In order to formulate self-emulsifying drug delivery system higher concentration of surfactant are required thus in the present study it is also aimed to develop SEDDS by using low concentration of surfactant. To reduce the surfactant concentration it is tried to develop an alternative system to increase the solubility of drug piroxicam by using mixed solvency concept providing potential solubilizer as well as it may support as cosurfactant system to emulsify and stabilize the SEDDS. Formulation development of SEDDS involved selection of excipients, viz., oil, surfactant and cosurfactant. Oil was selected on the basis of its solubilization capacity for piroxicam (a model drug). Surfactant and cosurfactants were selected on the basis of their solubilization capacity for piroxicam, miscibility with other formulation components, emulsifying ability, and observations of pseudo-ternary phase diagrams. The optimized formulation was prepared by spontaneous emulsification method and was filled in size zero capsules. It was further evaluated for various parameters like robustness to dilution, % transmittance, dispersibility test, droplet size, zeta potential, refractive index, cloud point, drug content, drug release, and dissolution profile.
Keyword: Mixed Solvency, Poorly soluble drug and SEDDS
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