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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and Evaluation of Bilayer Tablets of Metformin Hydrochloride and Ramipril

Author: UPLOADED BY-ADMIN, N. DEATTU, K. ELANGO, N. KOKILA, M. MOHANALAKSHMI
Abstract: The combination of an insulin sensitizer Metformin hydrochloride, and a blood pressure reducer Ramipril, represents a rational choice of agent for adequate control of blood glucose level and reduce the blood pressure by inclusion within a combination tablet. The combination of these two drugs in a single dosage form will reduce the frequency of administration and enhance the patient compliance. Swellable polymer Hydroxy propyl methyl cellulose K100M and non-swellable polymer Ethyl cellulose were used in combination in different ratios as matrix forming agent for sustaining metformin release effect. In-vitro dissolution study of sustained release formulations of F1, F2, F3, F4, F5 were performed. The amount of the drug metformin Sustained Release was released in 3,5,6,9 and 12 hours respectively in F5 formulation. Therefore the formulation F5 containing ethyl cellulose, hydroxy propyl methyl cellulose K100M (1:2) having a release profile up to 12 hours was selected for formulation of bilayered tablet. It was concluded that the concentration of polymers ethyl cellulose, hydroxy propyl methyl cellulose K100M (1:2 ratio) sustained the release of the drug. Polymer ratio (1:2) showed better performance among all formulations. In-vitro dissolution studies were performed for immediate release formulation ramipril layer and drug release was found to be 99.89% in 30 minutes and also, formulation of F5 has shown required release pattern and complies with all the evaluated parameters and comparable to the marketed formulation. The bilayer tablet prepared from optimized formula F5 was found to be the best-suited method for fixed dose combination of sustained release metformin hydrochloride and immediate release ramipril.
Keyword: Sustained release, Bilayer tablets, Formulation, Evaluation
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