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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of Organ Protective Ability of Cyanotis Fasciculata against Gentamicin Induced Nephrotoxicity

Author: UPLOADED BY-ADMIN, MURTHY R. L. N., NATARAJ H. N, S. RAMACHANDRA SETTY
Abstract: The present investigation was designed to evaluate the ability of the 70% hydro-alcoholic extract of Cyanotis fasciculata Var., fasciculata to combat nephrotoxicity in rats. Nephrotoxicity was induced in rats by administration of gentamicin 100mg/kg/day (i.p.) for eight days. The protective ability of the test extract was verified at 200 and 400mg/kg b.w. doses (p.o.). Where, the same demonstrated dose dependent decrement of elevated biochemical markers of nephrotoxicity along with significant restoration of protective-GSH levels and suppression of lipid peroxidase levels in tissues. Further, the remarkable renal-cellular rejuvenation found in histopathological studies was also enunciated the organ protective activity of the test extract. Some of the polyphenolic compounds found during HPTLC analysis of the test extrct might have contributed to the protection offered.
Keyword: CFEE, Gentamicin, Nephroprotection, BUN, Creatinine, polyphenolics, GSH, LPO.
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