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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Development and Evaluation of Terbutaline SulphateTransdermal Film

Author: UPLOADED BY-ADMIN, PATTANAYAK DHARMAJIT, DAS SAUMYA, SAHU NIGAM PRASAD
Abstract: The present investigation was aimed to formulate transdermal films incorporating Terbutaline Sulphate, a drug used in the treatment and management of Asthma. The two different polymers like ethyl cellulose and hydroxyl propyl methyl cellulose were used in varying ratios. Polyvinyl alcohol is used as backing membrane. The polymeric films were evaluated for their physical properties like physical appearance, thickness, drug content, moisture content, folding endurance, in-vitro evaluation and stability studies. The FT-IR spectra analysis of physical mixture in ratio 1:1 containing drug and polymer showed no shift in peak hence no interactions. Formulation TTS2 showed satisfactory results and hence was optimised.
Keyword: Terbutaline Sulphate, ethyl cellulose (EC), hydroxyl propyl methyl cellulose (HPMC)
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