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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and Evaluation of Sustained Release Matrix Tablets of Glipizide using Optimized Batch of Solid Dispersion

Author: UPLOADED BY-ADMIN, SURENDER VERMA, ARUNA RAWAT, MAHIMA KAUL, SAPNA SAINI
Abstract: The goal of the study is to develop once daily sustained release matrix tablet of Glipizide by applying solid dispersion technique for improving solubility. The matrix tablets of glipizide solid dispersion granules were prepared by wet granulation method using HPMC K 100 M as hydrophilic polymer and Eudragit RSPO as the hydrophobic polymer. Preformulation studies were carried out. The matrix tablets were evaluated for their physicochemical properties, in vitro drug release. To achieve complete drug release, various batches of solid dispersion of glipizide using water soluble carriers such as PEG (PEG 4000 as X1 and PEG 6000 as X2), were prepared as per the design expert (8.0.5) to optimize the drug release profile using response surface methodology (Face centered central composite design). DSC and FTIR were used to characterize the solid dispersions. No chemical interaction was found between Glipizide and polymers. Dissolution profile of matrix tablets containing solid dispersion has shown increase in the release rate compared to matrix tablets alone. From this study, it was clarified that solid dispersion granules was one of the promising sustained release system applying solid dispersion technique for the poorly water soluble drug.
Keyword: sustained release, glipizide, eudragit RSPO, HPMC K 100 M, PEG, solid dispersion
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