*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *       

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
No Data found.
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Venlafaxine Hydrochloride Triple - Layered Matrix Tablets: Preparation, Optimization, Characterization and In-Vitro Studies

Author: UPLOADED BY-ADMIN, LADANI ANIKET, DR RANJU RANA
Abstract: Triple layered matrix sustained release tablets of highly water soluble Venlafaxine hydrochloride using natural gum (Xanthan gum) and Hydroxypropyl methyl cellulose K-100M were prepared and formulation was optimized using 32 factorial design. The method adopted for preparation was hybrid wet granulation barrier layer technology, using Xanthan gum and HPMC K 100M as rate controlling ingredient in the middle sandwich layer and Xanthan gum in the barrier layers. The dissolution studies were performed in 900 ml of distilled water at 100 rpm using the USP XXIII basket apparatus up to 24 hrs. The triple layered tablets give the release pattern similar to that of reference product. The radar diagram and similarity factor f2 were used to evaluate the similarity of test product with the reference product. Effect of key formulation variables i.e. amount of Xanthan gum in the barrier layer and content of Hypromellose in the sandwich layer on the release of drug at 2 hrs time point and 18 hrs time point has been studied through optimization technique and the goodness of fit of the model was studied using ANOVA. Result reveals that the content of Xanthan gum in the barrier layer was major contributing factor for release at 2 hrs where as content of HPMC K-100 M in the sandwich layer was major contributing factor for release at 18 hr.
Keyword: Triple layered matrix sustained release tablets of highly water soluble Venlafaxine hydrochloride using natural gum (Xanthan gum) and Hydroxypropyl methyl cellulose K-100M were prepared and formulation was optimized using 32 factorial design. The method adopted for preparation was hybrid wet granulation barrier layer technology, using Xanthan gum and HPMC K 100M as rate controlling ingredient in the middle sandwich layer and Xanthan gum in the barrier layers. The dissolution studies were performed in 900 ml of distilled water at 100 rpm using the USP XXIII basket apparatus up to 24 hrs. The triple layered tablets give the release pattern similar to that of reference product. The radar diagram and similarity factor f2 were used to evaluate the similarity of test product with the reference product. Effect of key formulation variables i.e. amount of Xanthan gum in the barrier layer and content of Hypromellose in the sandwich layer on the release of drug at 2 hrs time point and 18 hrs time point has been studied through optimization technique and the goodness of fit of the model was studied using ANOVA. Result reveals that the content of Xanthan gum in the barrier layer was major contributing factor for release at 2 hrs where as content of HPMC K-100 M in the sandwich layer was major contributing factor for release at 18 hr.
Download: Request For Article
 
Clients

Clients

Clients

Clients

Clients
ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free