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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Venlafaxine Hydrochloride Triple - Layered Matrix Tablets: Preparation, Optimization, Characterization and In-Vitro Studies

Author: UPLOADED BY-ADMIN, LADANI ANIKET, DR RANJU RANA
Abstract: Triple layered matrix sustained release tablets of highly water soluble Venlafaxine hydrochloride using natural gum (Xanthan gum) and Hydroxypropyl methyl cellulose K-100M were prepared and formulation was optimized using 32 factorial design. The method adopted for preparation was hybrid wet granulation barrier layer technology, using Xanthan gum and HPMC K 100M as rate controlling ingredient in the middle sandwich layer and Xanthan gum in the barrier layers. The dissolution studies were performed in 900 ml of distilled water at 100 rpm using the USP XXIII basket apparatus up to 24 hrs. The triple layered tablets give the release pattern similar to that of reference product. The radar diagram and similarity factor f2 were used to evaluate the similarity of test product with the reference product. Effect of key formulation variables i.e. amount of Xanthan gum in the barrier layer and content of Hypromellose in the sandwich layer on the release of drug at 2 hrs time point and 18 hrs time point has been studied through optimization technique and the goodness of fit of the model was studied using ANOVA. Result reveals that the content of Xanthan gum in the barrier layer was major contributing factor for release at 2 hrs where as content of HPMC K-100 M in the sandwich layer was major contributing factor for release at 18 hr.
Keyword: Triple layered matrix sustained release tablets of highly water soluble Venlafaxine hydrochloride using natural gum (Xanthan gum) and Hydroxypropyl methyl cellulose K-100M were prepared and formulation was optimized using 32 factorial design. The method adopted for preparation was hybrid wet granulation barrier layer technology, using Xanthan gum and HPMC K 100M as rate controlling ingredient in the middle sandwich layer and Xanthan gum in the barrier layers. The dissolution studies were performed in 900 ml of distilled water at 100 rpm using the USP XXIII basket apparatus up to 24 hrs. The triple layered tablets give the release pattern similar to that of reference product. The radar diagram and similarity factor f2 were used to evaluate the similarity of test product with the reference product. Effect of key formulation variables i.e. amount of Xanthan gum in the barrier layer and content of Hypromellose in the sandwich layer on the release of drug at 2 hrs time point and 18 hrs time point has been studied through optimization technique and the goodness of fit of the model was studied using ANOVA. Result reveals that the content of Xanthan gum in the barrier layer was major contributing factor for release at 2 hrs where as content of HPMC K-100 M in the sandwich layer was major contributing factor for release at 18 hr.
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