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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Proniosomes: Recent Advancement In Novel Drug Delivery

Author: UPLOADED BY-ADMIN, RACHIYATA DUBEY, AMIT SINGH,, GARAUV K. SARAOGI, AKHILESH K. SINGHAI
Abstract: Several novel drug delivery systems have come into sight encircling various routes of administration to accomplish controlled and targeted drug delivery. Encapsulation of the drug in vesicular structures is one such system, which can be envisaged to extend the existence of the drug in systemic circulation and decrease the toxicity. Vesicular systems especially niosomes and liposomes are well recognized significant system for the transdermal route but the unstable nature of these carriers are the major dilemma in the development of vesicular system. New promising concept of provesicular system endows with the solution to get rid of the stability concern as well as provides an edge of higher entrapment efficiency over conventional systems. Proniosomes are water soluble carrier particles that are coated with surfactant and can be hydrated to form niosomal dispersion immediately before use on brief agitation in hot aqueous media. Hence, enhanced delivery of bioactive molecules through skin by proniosomal carrier opens new challenges and prospects for the expansion of novel improved therapies.
Keyword: Proniosomes, vesicular system, niosome, transdermal delivery
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