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Tat Inhibitors: A Novel Class of Anti-HIV Agents
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| Author:
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UPLOADED BY-ADMIN, NIRALI TRIVEDI, JAGRUTI MAURYA, GAURI JOSHI, UMESH UPADHYAY
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| Abstract:
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It is necessary to search for the novel class of anti-HIV (Human Immunodeficiency Virus) drugs and recent therapies for the
treatment of AIDS. Tat is a protein and a viral transactivator that is absolutely required for viral replication in vivo and in
vitro found in HIV genome. Tat protein is actively secreted by the HIV infected cells. It has been a surveyed that
monotherapy for AIDS has proved to have increased mortality rates as compared to the combination therapy. This leads to a
constant need to develop newer and newer anti-AIDS drugs which have the efficacy and safety required for continuation of
the therapy. Using Tat a target for developing newer anti AIDS drugs can open many new possibilities. Considering various
aspects of Tat both intracellular and extracellular it is a very potent candidate to act as a vaccine. Anti-Tat drugs can act by
various mechanisms of action as antagonist, receptor blocking and also on a genetic level when employed antisense Tat
decoys. Antisense Tat decoys hold great promise for application in both basic research and clinical treatment. It reduces HIV
viral load using patient T-cells which has been harvested, modified with an RNA antisense strand to the HIV viral envelope
protein, and re-infused into the patient during a planned lapse in retroviral drug therapy.Antisense RNA is an RNA transcript
that is complementary to endogenous mRNA. In other words, it is a non-coding strand complementary to the coding
sequence of RNA; this is similar to negative-sense viral RNA.
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| Keyword:
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AIDS, Extracellular Tat, Gene transcription, HIV genome, Tat inhibitors, Vaccine
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| EOI:
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| DOI:
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