IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Studies on the Physico-Chemical Interaction of Ranitidine with Excipients

Author: NEHA RAUT, MILIND JANRAO UMEKAR, NANDKISHOR KOTAGALE
Abstract: The objective of the present study was to evaluate the compatibility of the ranitidine, a histamine H2-receptor antagonist, with pharmaceutical excipients of common use including antioxidant, solvent/binders, superdisintegrant and glidant. RNH and its blends of 1:1 ratio with butylated hydroxytoluene, polyethylene glycol 6000, sodium starch glycolate and talc were stored at 25 ± 3 0C, 2 – 8 0C and accelerated conditions of 50 ± 2 0C, 40 ± 2 0C/75 ± 5 % RH for 3 months. The physical alterations were studied by visual observations as well as by microscopy; moisture gain was determined by weight changes and spectral changes observed with UV spectrophotometer. The physico-chemical properties and compatibilities of above excipients with ranitidine were evaluated using Differential thermal analysis and Differential scanning calorimetry to determine variations in peak temperatures and/or their associated enthalpy for drug/excipient combinations to analyze existence of interaction, if any. Thermal analysis was supplemented using Fourier Transform Infrared Spectroscopy to confirm the chemical interaction. Comparison of the thermoanalytical profiles of the mixtures with individual compounds gives an evidence of physico-chemical interaction, suggests incompatibility of above excipients at accelerated conditions.
Keyword: Ranitidine, Butylated hydroxytoluene, Polyethylene glycol 6000, Sodiumstarchglycolate, Talc, Interaction, Incompatibility
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free