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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Immunostimulating Complexes (ISCOMs): A Potential Adjuvant for Mucosal Vaccine Delivery

Author: UPLOADED BY-ADMIN, C. C. ANAJWALA, R. M. PATEL
Abstract: There is a need for non living adjuvant vectors that will allow a full range of local and systemic immune responses to orally administered purified antigens. Immunostimulating complexes (ISCOMs) are recently developed for vaccines preparation as adjuvant in an industrial use with increase safety, efficacy and convenience for demanding applications. The immunostimulating complex or ISCOM is one adjuvant with multiple adjuvant properties. ISCOM have the ability to stimulate the cell-mediated immune system as well as to enhance antibody production and have the advantage that only a low dose is needed for adjuvant activity. Because ISCOM-based vaccines have now progressed to phase I and II human trials, This review documents our present understanding of the structure, preparation and functional properties of ISCOMs and will describe some recent development and modifications that have been made to enable ISCOMs to be suitable for human applications.
Keyword: Adjuvant, Immune Response, ISCOMs.
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