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Formulation and evaluation of transdermal patches comprising of Lovastatin
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| Author:
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SANJAY SHARMA, MANOJ GOYAL
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| Abstract:
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Lovastatin is a cholesterol-lowering agent that belongs to the class of medications called statins. Transdermal patches were prepared by solvent evaporation technique. The matrix type transdermal drug delivery system was prepared using different proportions of ethyl cellulose and polyvinyl pyrrolidone, which are hydrophobic and hydrophilic polymer respectively. The backing membrane was prepared using polyvinyl alcohol and dibutyl phthalate used as plasticizer. Dimetyl sulfoxide was added as permeation enhancer.
Several physicochemical parameters like moisture content, moisture loss, thickness, film folding endurance, tensile strength and film elongation were evaluated. For all the formulations, skin permeation of the drug through Human cadaver was studied using Frenz- diffusion cell. Formulations with highest proportion of polyvinyl pyrrolidone shows enhance release whereas increasing proportion of ethyl cellulose produces a prolonged regimen of sustained drug delivery through transdermal route for a period of more than a day. The present study has demonstrated the potential of the fabricated matrix films for prolonged release of Lovastatin.
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| Keyword:
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Lovastatin, transdermal therapeutic system, polyvinyl alcohol, ethyl cellulose, polyvinyl pyrrolidone.
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| EOI:
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| DOI:
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