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Effect of Size Reduction on Dissolution Enhancement of Simvastatin through Nanotechnology
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UPLOADED BY-ADMIN, S. PUNITHA, KL.SENTHIL KUMAR
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| Abstract:
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The Simvastatin Nanoparticle were prepared by solvent displacement method coupled with ultrasonication by optimizing the various concentration of stabilizer polyvinyl alcohol and was evaluated for its physicochemical properties. The mean size of the nanoparticle was increased where the polyvinyl alcohol concentration increased also affects the charge distribution on the nanoparticle. The optimum polyvinyl alcohol concentration was found to be 1% with mean particle size of 116nm ± 0.7nm with the zeta potential as -13.4mV. The Scanning Electron Microscopic image of nanoparticle shows drastic change in morphology as compared to unprocessed drug. The differential scanning calorimetry studies evidenced the changes in crystalline nature of simvastatin. Powder X-ray diffraction studies shows that there was absence of crystalline diffraction peaks. The 100% drug release was achieved at five minutes as compared to unprocessed drug. It was concluded, that the effective particle size reduction has been achieved, by this technique to produce nanoparticle which might help in improving the bioavailability of poorly soluble drug.
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Solvent displacement method, polyvinyl alcohol, X-ray powder diffraction, Ultrasonication
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