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Protective Effect of Normacid, a Herbomineral Formulation, Against Free Radical-Induced Cardiac and Renal Damage
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| Author:
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UPLOADED BY-ADMIN, PALLAVI BAFNA, R. BALARAMAN
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| Abstract:
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Normacid, a herbomineral formulation, was investigated for its protective effect against isoproterenol-induced myocardial infarction and cisplatin-induced renal damage, both the models representing free-radical induced oxidative stress. The effect of Normacid at various dose levels (125, 250, 500 and 1000 mg/kg, p.o.) on the serum levels of cardiac (isoproterenol model) and renal (cisplatin model) markers as well as on the tissue antioxidant parameters were studied in rats. Normacid was found to reduce the levels of serum creatine kinase, glutamic oxaloacetate transaminase, lactate dehydrogenase and uric acid in isoproterenol-induced cardiac damage. In cisplatin-induced renal damage, Normacid reduced the serum levels of creatinine, urea, blood urea nitrogen and uric acid. It was further found that administration of Normacid increased the levels of superoxide dismutase, catalase, reduced glutathione and membrane bound enzymes like Ca2+ATPase, Mg2+ATPase and Na+K+ATPase and decreased lipid peroxidation in heart and kidney in isoproterenol-induced myocardial necrosis and cisplatin-induced renal damage, respectively. Normacid, by virtue of its antioxidant activity, elicited protective effect on the heart and kidneys against the oxidative damage induced by isoproterenol and cisplatin, respectively.
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Isoproterenol, cisplatin, lipid peroxidation, superoxide dismutase, catalase, reduced glutathione.
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