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Particle Size Distribution and Aspect Ratio Analysis of Ofloxacin Mucoadhesive Polymeric Suspension using Scanning Electron Microscopy
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UPLOADED BY-ADMIN, SUBHASHREE SAHOO, CHANDRA KANTI CHAKRABORTI, SUBASH CHANDRA MISHRA
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| Abstract:
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Three types of mucoadhesive suspension of Ofloxacin were formulated by taking Carbopol940, Carbopol934 and Hydroxypropyl methylcellulose polymers with the help of ultrasonication method. The aim of this study design was to investigate the morphologies and mechanical properties of the resultant formulations. The dispersion of particle was observed by Scanning electron microscopy technique. The particle size distribution and aspect ratio of particles in the polymeric suspensions were obtained from Scanning electron microscopic image analysis. It was found that the imaging displays directly the micron level dispersion of particles in polymeric formulations. Considering graphical analysis, the maximum particle size ranges for formulations containing Ofloxacin with Carbopol940, Ofloxacin with Carbopol934, and Ofloxacin with Hydroxypropyl methylcellulose are from 2-4 µm, 10-15 µm and 4-6 µm, respectively. In rod-like particles whose shapes are characterized by the two major and minor lengths of the particle, the length/width ratios are satisfactorily consistent with the aspect ratio value evaluated from the instrumental measurements. From our results it can be concluded that formulations containing Ofloxacin with Carbopol934, and Ofloxacin with Hydroxypropyl methylcellulose are more homogeneous and stable with good bioavailability and penetration capacity because they have lesser standard deviation and co-efficient of variation in aspect ratio analysis. The particle size distribution and aspect ratio analysis and degree of dispersion in the formulation give insights into the modification of mechanical properties of the mucoadhesive formulation studied.
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Ofloxacin, C934, C940, HPMC, SEM, PSD, Aspect ratio
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