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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Estimation of Lafutidine in Tablet Dosage form by RP-HPLC

Author: UPLOADED BY-ADMIN, RAVI PRATAP PULLA, B. S. SASTRY, Y. RAJENDRA PRASAD, N. APPALA RAJU
Abstract: A simple, precise, rapid and accurate Reverse Phase HPLC method was developed for the estimation of Lafutidine in tablet dosage form. An Inertsil ODS-3V, RP C18, 250x4.6 mm, column with 5 µm particle size and the mobile phase consisting of 0.02M Potassium Dihydrogen Orthophosphate + 0.02M Dipotassium Hydrogen Orthophosphate in water pH: 3.2 adjusted with Acetonitrile (30:70 v/v). Acetonitrile in the isocratic mode was used. The flow rate was 1.0 ml/min and the effluents were monitored at 215 nm. The retention time was 4.220 min. The detector response was linear in the concentration of 8-96 mcg/mL for Lafutidine. The respective linear regression equation being Y= 60153.876x + 9366.2787 for Lafutidine. The Limit of Detection (LOD) and The Limit of Quantification (LOQ) were 0.08 mcg and 0.24 mcg respectively for Lafutidine. The percentage assay of Lafutidine was 99.50 %. The method was validated by determining its accuracy, precision and system suitability. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Lafutidine in bulk drug and in its pharmaceutical dosage forms.
Keyword: Lafutidine, RP-HPLC, Estimation, Tablets.
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