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Design and Evaluation of Ocular Inserts of Moxifloxacin Hydrochloride
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UPLOADED BY-ADMIN, SHRISHAIL S PATIL, DODDAYYA HIREMATH , PRADEEP REDDY, KRANTHI KUMAR SIRSE
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The objective of the present work was to develop ocular inserts of a highly water soluble, novel fluoroquinolone moxifloxacin hydrochloride and to evaluate their potential for controlled ocular delivery. Drug reservoir films were prepared using hydrophilic polymers like hydroxylpropropyl methylcellulose and polyvinyl pyrrolidine alone and in combinations, while rate-controlling membrane was prepared using hydrophobic polymer ethyl cellulose by film casting method. The physicochemical properties of the prepared ocular inserts was found to be satisfactory with respect to appearance, thickness, folding endurance, weight variation and drug content. In vitro release profiles indicated that, irrespective of the polymer used, its increase in concentration has drastically retarded the release of moxifloxacin Hydrochloride. The reservoir films prepared using hydroxylpropropyl methylcellulose gave more controlled release than the polyvinyl pyrrolidine in similar concentrations. However, neither hydroxylpropropyl methylcellulose nor polyvinyl pyrrolidine could control the release of highly water-soluble drug moxifloxacin hydrochloride for a period of 24 hrs and thus indicated the need for a rate controlling membrane. Controlled release over a period of 24 hrs was obtained from formulation HEC3 containing 6% hydroxylpropropyl methylcellulose as reservoir film and 2% ethyl cellulose as rate limiting membrane. The optimized formulation (HEC3) showed no signs of ocular irritation and exhibited the controlled drug release over a period of 24 hrs when inserted in the rabbit eyes. Good correlation between in vitro and in vivo drug release was observed (r2=0.991). Non-Fickian diffusion controlled zero order drug release mechanism was observed for optimised formulations. Compatibility studies revealed the absence of any interaction between drug and polymers used. Thus, the ocular inserts of moxifloxacin hydrochloride were successfully designed and the results showed promising results under both in vitro and in vivo conditions.
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Moxifloxacin Hydrochloride; Ocular Inserts; Controlled Release; In Vitro In Vivo Studies.
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