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Pelletization Techniques- A Review
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UPLOADED BY-ADMIN, DADHICHI K THAKKAR, BHAVESH SHIYANI, GAURAV PATEL, PRATIK PATEL, , RAVI PATEL, YASHVANTSINH CHAWDA
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| Abstract:
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Compared to single-unit dosage forms, oral multiparticulate drug-delivery systems offer biopharmaceutical advantages in terms of a more even and predictable distribution and transportation in the gastro-intestinal tract. Pelletization is a technique which converts fine powder particles into pellets used as multiparticulate dosage forms. . Although pellets have been used in the pharmaceutical industry for more than four decades, with the advent of controlled release technology, that the full impact of the inherent advantages of pellets over single unit dosage forms have been realized, not only has focused on refining and optimizing existing pelletization techniques, but also focused on the development of novel approaches and procedures for manufacturing of pellets. The present review outlines the manufacturing and evaluation of pellets. The manufacturing techniques include layering, cryopelletization, freeze pelletization, and extrusion spheronization. Characterization of pellets is discussed with reference to the particle size distribution, surface area, porosity, density, hardness, friability and tensile strength of pellets.
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| Keyword:
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Pelletization, Extrusion, Spheronization, Cryopelletiztion
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