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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Spectrophotometric Simultaneous Determination Of Montelukast Sodium and Desloratidine in Combined Dosage Form By Simultaneous Estimation Method

Author: TUKARM KALYANKAR, RANJEET HARIBHAU KOKATE
Abstract: A new, simple, economic, rapid and novel spectrophotometric method has been developed for simultaneous estimation of Desloratidine and Montelukast sodium. The method involved measurement of absorbance at ?max of 242 nm and 283 nm, for Desloratidine and Montelukast sodium respectively. Desloratidine and Montelukast sodium obeyed the Beer’s law in concentration range of 0.1-0.6 µg/ mL and 0.2-1.2 µg/ mL respectively. The proposed method is recommended for routine analysis since it is rapid, simple, accurate, precise, sensitive and specific. This paper describes the development and validation of Ultravoilet spectroscopic method for simultaneous estimation of Desloratidine and Montelukast sodium in combined tablet dosage form.
Keyword: Montelukast sodium, Desloratidine, Beer’s law.
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