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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and evaluation of transdermal patches of glibenclamide

Author: UPLOADED BY-ADMIN, MANISH P PATEL, M M PATEL, K N PATEL, D R PATEL, U L PATEL
Abstract: Glibenclamide, a hypoglycemic agent belonging to sulphonyl urea class. Sulphonyl urea causes hypoglycemia by stimulating insulin release from pancreas beta cells. Sulphonyl urea also may further increased insulin level by reducing hepatic clearance of the hormone. An attempt has been made to formulate transdermal patches using Eudragit RL 100, Eudragit RS 100, Polyvinyl pyrollidone ( PVP) as polymers, glycerol and propylene glycol as a plasticizers and Span 80 as a permeation enhancer by solvent casting method with aim of to study the release kinetics of drug with a view to reduce the dose frequency, improving patient compliance, greater therapeutic efficacy and to prevent its first pass metabolism to achieve a controlled drug release and overcome some draw backs such as gastric disturbance, hepato toxicity with improved bioavailability. The prepared transdermal patches were then evaluated for uniformity of thickness, weight variation, hardness, surface pH, tensile strength, swelling index (%), folding endurance, water vapor permeability, drug content. In vitro drug release studies of formulated patches were performed by studying the diffusion through human cadaver skin. The IR analysis of the sample was carried out for qualitative compound identification using KBr disc method. Out of eight formulations prepared, the formulation containing Eudragit RL 100 with propylene glycol as plasticizer showed complete and prolonged release with 98.02 % at the end of 24 hours. The data from the In vitro release was fitted to various kinetic models like zero order, first order, and Higuchi equations to determine the kinetics of drug release.
Keyword: Glibenclamide, transdermal patches, Eudragit RS100, Eudragit RL100, glycerol,Propylene glycol, In vitro release
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