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FORMULATION DEVELOPMENT OF NIFEDIPINE NANOSUSPENSION FOR IMPROVING DISSOLUTION VELOCITY.
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| Author:
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ANAND SHAH, SUNNY SHAH, VIPUL PATEL
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| Abstract:
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Poorly water-soluble drugs such as nifedipine (NF) (solubility ~20µ/ml) put forward challenging problems in drug formulation as poor solubility is generally associated to poor dissolution characteristics which may lead to poor oral bioavailability. In order to enhance these characteristics, preparation of nifedipine nanosuspension has been achieved using media milling technique. We investigated the nanoparticle formation of NF via considering the effects of drug-to-stabilizer ratio and amount of beads (zirconium oxide) on the mean particle size, and dissolution properties of NF. It was observed that optimization of drug-to-stabilizer ratio and amount of beads allowed the formation of nanosuspensions with a mean particle size of 283 nm. Differential Scanning calorimetry studies confirmed that the crystallinity of the drug was maintained after the particle size reduction suggesting that improved dissolution of NF nanosusensions could be attributed to reduction in particle size.
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| Keyword:
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Nanosuspension, Dissolution Enhancement, Media Milling, Mean Particle Size
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| EOI:
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| DOI:
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| Download:
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