|
The Association between the Causal Factors and Perforated Prepyloric Ulcer: A Case Series
|
|
| Author:
|
, DR.SWETA ATHAWALE, DR MADHURI W. BARABDE, DR RAJIVA M. MULMULE, DR SHYAM BHAGAT, DR SHARVARI SURVE
|
| Abstract:
|
Background: Prepyloric perforation is a serious complication of peptic ulcer disease that can lead to generalized peritonitis and sepsis if not promptly diagnosed and managed. It remains a significant surgical emergency, particularly in developing countries. Identifying changing etiological patterns and risk factors such as lifestyle habits is crucial for optimizing prevention and treatment strategies.
Methods: A prospective observational study was conducted over a 6-month period in a tertiary care center. Thirty patients presenting with signs of peritonitis were intraoperatively confirmed to have prepyloric or duodenal perforations. Detailed clinical histories, biochemical parameters, and lifestyle factors including smoking, alcohol use, and Helicobacter pylori status were recorded. All patients underwent emergency Graham’s omental patch repair, and postoperative outcomes were analyzed.
Results: Among 30 patients, 83.3% had prepyloric perforations, predominantly affecting young males (mean age 28 years). Significant associations were observed with smoking (83.3%) and alcohol intake (66.6%), while Helicobacter pylori infection and NSAID use were less frequent. Most patients had favorable postoperative recovery. No mortality was reported.
Conclusions: Prepyloric perforation remains a prevalent surgical emergency among young males, increasingly associated with modifiable risk factors such as smoking and alcohol use rather than traditional causes like NSAIDs and H. pylori. Early surgical intervention with Graham’s patch repair continues to offer excellent outcomes, emphasizing the need for preventive public health strategies targeting lifestyle modification.
|
| Keyword:
|
Peptic ulcer disease, prepyloric perforation, Helicobacter pylori, NSAIDs, smoking, alcohol
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2025.17.03.011
|
| Download:
|
Request For Article
|
|
|