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Revolutionizing TBI Management: The Role of Nanoparticles
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| Author:
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RITIKA, SHIVANI SHARMA, DINESH KAUSHIK
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| Abstract:
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Traumatic brain injury (TBI) is a significant cause of death and disability in children and young people around the world.Traumatic brain injuries are categorised as primary injuries and secondary injuries. Damage to neuronal and glial tissues, as well as a breach in the blood-brain barrier (BBB), cause localised inflammation and subsequent neurodegeneration in primary traumas. Alternatively, subsequent injuries are characterised by reduced glial reactivity due to cerebral ischaemia, a decline in oligodendrocyte populations, and a prolonged elevation ssof proinflammatory cytokines. The development of efficient treatments and diagnostics has been hampered by the intricate pathology of TBI that involves the BBB. As a result, creating innovative methods to target the BBB is crucial. TBI-induced BBB leakage may present chances for therapeutic administration using nanoparticles (NP). This review's main goals are to assess the NP-based techniques used in preclinical TBI models and offer suggestions for better NP-based diagnostic or therapeutic approaches. There is a conversation about using organic or artificial nanoparticles for treating traumatic brain injury (TBI). Finally, it is emphasized to create open chances for NP researchers to begin research in TBI by highlighting areas where improved NP-mediated delivery could increase target involvement.
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| Keyword:
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TBI, nanoparticle, drug delivery, neurotrauma, blood-brain barrier
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2025.17.03.009
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| Download:
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