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Exploring Moringa Oleifera As A Novel Therapeutic Agent For Pacliaxel Induced Neuropathic Pain In Animal Model
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| Author:
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DR S.K. PRIYADHARSHINI, P. MIRUNALINI, DR K. BHUVANESWARI
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| Abstract:
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Neuropathic pain is one of the most common pain observed in many uncontrolled Diabetic patients and as a Drug induced adverse reaction. Many drugs are available to treat but causes drowsiness and take long time to heal or suppress the pain. Neuropathic pain may include tactile hypersensitivity and hyperalgesia. Moringa oleifera is a common edible green leaf rich in B12 and folic acid and few GABA like material, proved with few animal modelslike epilepsy. The aim of the study is to observe the neuroprotective effect of Moringa oleifera and behavioural changes in Neuropathic Pain induced Rat model. The first step is analysis using FTIR. Presence of GABA like compound in the sample. The second step is the Animal study: Out of 60 Male Wistar Albino Rats (150-250g) 32 will be selected post screening. IP Paclitaxel injections were given on days 0, 2, 4, 6 and on 14th day.Neuropathic Pain have been induced. Then, the animals were split into 4 groups with 8 animals each and will be given gabapentin 60mg/kg, MO 400mg/kg, MO 600mg/kg through oral route OD (once daily) and one group as disease control group. Hot plate test, Cold allodynia test, Acetone drop tests were performed every week for 4 weeks.On statistical analysis using ONE WAY ANOVA, the Moringa groups showed statistically significant responses compared to other groups. Behavioural side effects such as drowsiness, weight loss seen in Gabapentin groups was absent in Moringa groups. Moringa oleifera produced significant reduction in hyperalgesia and allodynia effects on the experimental models.
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| Keyword:
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FTIR, Moringaoleifera, Gabapentin, Neuropathic Pain, Hyperalgesia, Allodynia
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2025.17.03.008
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| Download:
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