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Molecular Characterization and Phytochemical Analysis of Moringa Resins
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| Author:
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NITHIN SAI KAVARTHAPU SURIYANARAYANAN, VIGNESH VENKATESAN, DR GOWRI SHANKAR BAGVANANTHAM ANDAVAN
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| Abstract:
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The increasing resistance to conventional antibiotics and chronic disease medications underscores the urgent need for alternative therapeutic agents derived from natural sources. This study investigates the underexplored resin of Moringa oleifera, known for its diverse ethnopharmacological applications, focusing on its phytochemical composition and therapeutic potential. The resin was extracted using ethanol and analyzed via Gas Chromatography–Mass Spectrometry (GC-MS), revealing a diverse profile of bioactive compounds including flavonoid glycosides, oxygenated diterpenes, and pyrrolidine alkaloids. Qualitative phytochemical screening confirmed the presence of alkaloids, flavonoids, cardiac glycosides, and saponins. The extract demonstrated antimicrobial activity against Staphylococcus aureus and Escherichia coli, with inhibition zones increasing with concentration. In silico molecular docking, performed using PyRx and visualized through PyMOL and LigPlot+, identified strong interactions between key bioactives and multiple protein targets implicated in antibacterial, antifungal, anti-inflammatory, and anti-diabetic pathways. The standout compound, 2,5-Bis(1,1,3,3-tetramethylbutyl)-2,5-cyclohexadiene-1,4 dione, exhibited high binding affinities and favorable ADMET properties. This integrated approach not only validates the traditional uses of Moringa resin but also establishes a novel framework for natural product-based drug discovery.
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| Keyword:
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Antibiotics, Chronic Diseases, ethnopharmacological applications, GC-MS and Pyrx and PyMOL
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2025.17.03.004
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| Download:
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