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Preparation and Characterization of Zinc Oxide Nanoparticles for Antibcterial Activity
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| Author:
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, RAHUL SHARMA, DEVENDER CHAUHAN, SEEMA ROHILLA, BIRENDER SINGH
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| Abstract:
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Drug delivery systems are the target of nanoparticles. It is a sophisticated method. The size of nanoparticles ranges from 1 to 100 nanometers. It can be administered orally, nasally, or parenterally, among other ways. Nanoparticles can be classified as organic, inorganic, or carbon-based. Bacteria with antimicrobial activity of ZnO nanoparticles are often identified by their cytoplasm, cell wall, and cell membrane. The chemical precipitation approach was used to create linezolid linked zinc oxide nanoparticles. Linezolid (All well Pharmaceuticals), Zinc Sulfate (Merck Life Sciences Pvt. Ltd.),Sodium Hydroxide (Thermo Fisher Scientific Pvt. Ltd.), Chloroform (Thermo Fisher Scientific India Pvt. Ltd.), Methanol (Finar Limited). Linezolid was found to be soluble in methanol and chloroform. M.P of Linezolid found to be 1810C. Analytical method for the estimation of unknown concentration of drug was developed by preparing calibration curve in chloroform. The maximum absorption was found to be 252nm. Linezolid coupled Zinc Oxide NPs were prepared by chemical precipitation method. SEM used to determine surface morphology and Shape of nanoparticles. Upon characterization of nanoparticles, the micronized structure of Nzo-NPs found to be in range of 1-40nm. PXRD pattern of ZnO-NPs, Linezolid-ZnO-NPs, Physical mixture of linezolid ZnO NPs were measured between 5o and 80o. ZnO NPs demonstrated superior bacteriostatic efficacy against every pathogen examined, according to the data. The antibacterial activity rose as ZnO NP concentration rose and particle size decreased. According to the zone of inhibition seen against both Gram-positive and Gram-negative bacteria, ZnO NPs show promise as antibacterial agents. Because of their many medicinal qualities, ZnO NPs can be used as valuable therapeutic agents and would serve as a safe nano oxide form of zinc, according to the current study. Additional research is required to determine the mechanism by which ZnO NPs improve action against antibacterial compounds.
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| Keyword:
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Nanoparticles, Zinc Oxide, Linezolids, Bacteriostatisc, Target drug delivery.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2025.17.02.009
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| Download:
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