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A Review on Understanding the Motor Neuron Disease
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| Author:
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RIYA ATUL PATIL, ABHISHEK BADRINATH ETHAPE
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| Abstract:
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Motor neuron disease(MND) is a progressive neurodegenerative condition that generally manifests in majority and culminates in respiratory failure within three to five times of symptom onset. This deterioration results from the gradational decaying of branch, bulbar, and respiratory musculature. Although the maturity of MND cases arise sporadically, roughly 10% follow a heritable pattern. Recent inheritable examinations have led to the identification of two fresh genes intertwined in the complaint, contributing to a broader understanding of its pathogenesis. Clinical evaluation remains the foundation of opinion, which frequently poses a challenge due to lapping donations with treatable conditions that must be barred before a definitive opinion can be made. Riluzole, presently the only pharmacologic agent approved specifically for amyotrophic side sclerosis(ALS), provides a modest survival benefit of three to four months. Accordingly, remedial strategies largely concentrate on easing symptoms, conserving autonomy, and enhancing quality of life. nutritive decline is a significant prognostic factor, with malnutrition relating with poorer issues. While enteral feeding is advised for suitable campaigners, substantiation supporting its impact on overall survival is limited. In cases with ALS passing respiratory decline, non-invasive positive pressure ventilation has been shown to extend survival and ameliorate quality of life, especially in those with saved or mildly affected bulbar function.
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| Keyword:
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Neurodegeneration, Amyotrophic Lateral Sclerosis, SOD1, Riluzole, Dysarthria, Muscle Cramps.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2025.17.02.007
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| Download:
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Request For Article
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