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Unveiling a Paradox: Vortioxetine-Associated Restless Legs Syndrome
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| Author:
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DR.ANNWESHA CHAUDHURY, MBBS, DR. AYUSH JAIN, MD, DNB, DR. SHIKHA DWIVEDI, MD, DR. LIBIN SANJEEV L, MBBS, DR.SANJAY GAUR, MD
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| Abstract:
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Background: Vortioxetine is widely recognized for its efficacy in treating major depressive disorder (MDD) and anxiety. However, its potential side effects include the induction of restless leg syndrome (RLS), a condition less frequently associated with antidepressant therapies.
Objective: This case series aims to explore the occurrence of RLS following vortioxetine treatment in patients diagnosed with MDD, to better understand the clinical characteristics of this association.
Methods: We present a detailed analysis of six cases where individuals receiving vortioxetine for MDD developed RLS. Each case was thoroughly examined to document the onset and progression of RLS, alongside the psychiatric benefits and adverse effects observed during vortioxetine therapy.
Results: All six patients developed symptoms of RLS subsequent to the initiation of vortioxetine. The clinical presentation and severity of RLS varied among patients, complicating the management of their underlying psychiatric conditions. Adjustments in therapeutic strategies were required for some patients to balance the benefits of depression and anxiety alleviation with the discomfort of RLS.
Conclusion: This case series contributes preliminary evidence suggesting a potential link between vortioxetine treatment and the development of RLS in patients with MDD. Clinicians should be vigilant for symptoms of RLS in patients prescribed vortioxetine. Further studies are necessary to elucidate the mechanisms behind this association and to refine treatment approaches that mitigate this adverse effect while effectively managing the primary psychiatric conditions.
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| Keyword:
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RLS, MDD, vortioxetine, treatment
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2025.17.01.004
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| Download:
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