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Prevalence of Human Papillomavirus Induced Head and Neck Squamous Cell Cancers in Indian Subcontinent: A Review Article
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| Author:
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SANYUKTHA T, CHANDRIKA R
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| Abstract:
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Introduction: Oral cancer pretences a substantial global health challenge, with approximately 20 per 100,000 population and accounts for over 30% of all cancers in India. Human papillomavirus (HPV) has emerged as a key risk factor for the development of Head and neck cancer, constituting around 60% of all oral cancer cases around the world. This review aims to present a comprehensive overview of the current relationship between HPV and oral cancer, covering aspects such as detectionand prevalence rate.
Methods: A comprehensive literature search was conducted using PubMED and Google scholar databases to identify studies published in English from January 2012 to January 2022 that investigated the association between HPV and oral cancer and relevant articles were selected.
Results: The literature search yielded 32 studies that met our inclusion criteria. Our analysis revealed that HPV is a common finding in oral cancer, with a pooled prevalence rate of 22.4%. HPV-16, followed by HPV-18 was the prominent genotypes detected in HPV induced Head and neck cancer.
Conclusions: HPV considerably contributes to the onset of Head and neck cancer, and identifying it early can serve as an indicator for diagnosis and prognosis which in turn aids to formulate successful prevention and
treatment approaches. Immunization against HPV shows potential for decreasing the occurrence of Head and neck cancer linked to HPV.
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| Keyword:
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HPV, HNSCC, OSCC,PCR, IHC
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2024.16.03.004
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| Download:
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Request For Article
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