|
Development and Evaluation of a self-emulsifying drug delivery system (SEDDS) containing Nimodipine
|
|
| Author:
|
MANOJ B. JOGRANA, PRAGNESH V. PATANI
|
| Abstract:
|
The study aimed to develop and evaluate a liquid self-emulsifying formulation loaded with Nimodipine, focusing on solubility, emulsification, and in vitro release characteristics. Various excipients were screened, and Capmul MCM was selected as the oil phase due to its high solubilization capacity. Surfactants such as Tween 80 and co-surfactants like PEG 400 were chosen based on their emulsification effectiveness. Pseudo-ternary phase diagrams were constructed to optimize the formulation, with formulation F7 being identified as the optimized batch. This formulation exhibited excellent thermodynamic stability, rapid self-emulsification, minimal globule size, and high transmittance. In vitro release studies showed sustained drug release, indicating potential for improved bioavailability. Pharmacokinetic analysis revealed enhanced efficacy compared to a marketed tablet. The developed self-emulsifying drug delivery system shows promise for enhancing the oral delivery and therapeutic efficacy of Nimodipine formulations.
|
| Keyword:
|
Self-emulsifying drug delivery system (SEDDS), Nimodipine.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2024.16.02.007
|
| Download:
|
Request For Article
|
|
|