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Effect Of Znfe2o3 @ Ag Nanocomposite On Lipopolysaccharide Extracted From Pseudomonas Aeruginosa Clinical Isolates
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| Author:
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MOHAMMED WAIL KOLAIB, FAESAL GHAZE HASSAN, SUHA MAHER ABED
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| Abstract:
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Burns and wounds are very disabling afflictions and have considerable morbidity and death rates globally. The risk of infection increases, impeding healing and potentially leading to sepsis. Antibiotic resistance, which is
mostly caused by the use of systemic antibiotics to treat localized infections, is another barrier to recovery. Nanotechnology has successfully discovered techniques to include antibiotics in nanoparticles for the treatment of wounds and burns. This study focuses on recent breakthroughs in the use of ZnFe2O3 @ Ag nanocomposite to treat burn wound infections. Effects impact nanocomposites on lipopolysaccharide in Gram negative bacteria, including
multidrug-resistant microorganisms (MDR), especially Pseudomonas
aeruginosa. The study found thatwhen Pseudomonas aeruginosa isolated from Burns and Wounds was exposed to the ZnFe2O3@Ag nanocomposite at three concentrations of 25, 12.5, and 6.25 mg/ml, and the polysaccharide was extracted from the sample before, and after exposure. Certain bands disappeared and new bands appeared. This is because the exposure led to mutations in the production of new lipopolysaccharides, resulting in a different molecular weight and affecting the binding to the cell surface. It has been proven that nanoparticles have a synergistic effect against the lipopolysaccharide produced by P. aeruginosa isolates, which could potentially help in the production of vaccines to limit the spread of burn and wound infections.
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| Keyword:
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ZnFe2O3, nanocomposite, Lipopolysaccharide
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2024.16.02.006
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| Download:
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Request For Article
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