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Integrated Review of Hepatoprotective and Hepatotoxic Drug
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AMITABH SHARMA, SURYA PRAKASH GUPTA, ABU TAHIR
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| Abstract:
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It was shown that Polygonum persicaria lessened the liver damage caused by CCl4. Five groups of twenty albino wistar rats were created: control, CCl4-induced hepatotoxicity, and hepatotoxicity using 200 and 400 mg/kg body weight of Polygonum persicaria. After 14 days, the rats were scarified. Twelve rats were used in the toxicity experiments. Three groups were created at random for the participants: control, 200 and 400 mg/kg Polygonum persicaria, and one group receiving standard silymarin treatment. Samples of blood were drawn for biochemical analysis. Rats in the CCl4-induced hepatotoxic group exhibited mean serum concentrations of AST, ALT, ALP, and TB that were considerably greater than those in the control group (P<0.001). Polygonum persicaria treatment groups showed notable decreases in several metrics. Anemia was noted in the CCl4-treated group. Rats given CCl4 treatment experienced less significant hepatic fatty changes. Except for a few isolated fatty changes in the liver at higher doses, same amounts of the plant had no effect on the parameters evaluated above. The presence of liver injury was confirmed by histological changes. Natural hepatoprotective products include chamomile capitula, and Andrographic paniculata. Marianum Silybum
StecheamichuacanaCoccinia grandis Flacourtia indica Calendula Wedelia Annona squamosa, Carica ficus Lepidium vulgare, Solanum nigrum, Swertia chirata, Polycystum sargassum, Given that Phellodendronemblica Combining Picrorhizakurroa with Curcuma longa Azadirachta indica, Aegle MarmelosRoxburghii Cassia Astragalus staminus, Curcas jatropha Foeniculum vulgare, Foenum graecum, Alba Eclipta, Trigonella, The Garcinia mangostana Linn is reviewed.
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| Keyword:
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CCl4, Hepatoprotective, Polygonum persicaria, Silymarin, Biochemical analysis, Histopathology.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.04.022
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| Download:
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