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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Efficacy Of Crystalloids Vs. Colloids In Preloading In Patients For Spinal Anaesthesia - A Comparative Study

Author: , SUBBALAKSHMI T.D.P, T.V.V.S.V PRASAD, SRINIVASA RAO TATAVARTI
Abstract: Introduction While there are many benefits to spinal block, such as sensory block, muscle relaxation, and aware patient, a common and significant issue with spinal anesthesia is quick and severe hypotension brought on by sympathetic blocking.Preloading is a tried-and true technique to stop spinal anesthesia-related hypotension.AIM:In order to prevent spinal hypotension, this study compares the effectiveness of ringer lactate solution, a crystalloid, with hetastarch, a colloidal, for volume preloading. Materials And Methods: Informed consent was taken from a total of 150 patients of ASA grade I,carried out in Government General Hospital,Srikakulam. The study subjects were allocated into 3 groups of 50 each. Group A (50 patients)- without preloading, Group B (50 patients) - Crystalloid group - received preload infusion of Ringer lactate solution, 1000 ml, Group C (50 patients) - Colloid group - received preload infusion of 6% Hydroxy Ethyl starch, 500 ml. Conclusion: From this study we conclude that 6% hydroxyethyl starch is better choice for prevention of hypotension following spinal anaesthesia in caesarian section in comparison to crystalloids – Ringer Lactate solution.
Keyword: Crystalloid – Colloid – Ringer lactate – Hetastarch – Preloading – Spinal anaesthesia – Hypotension.
DOI: https://doi.org/10.31838/ijpr/2023.15.01.019
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