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Comparing the efficacy of Olopatadine Hydrochloride and Alcaftadine in the treatment of Allergic Conjunctivitis
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| Author:
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B.SANDHYA, TEENA ROSE.D.C, UDIT SAGAR
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| Abstract:
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Aim: The study’s goals were to (1) To assess which of the two drugs (alcaftadine, olopatadine HCL) alleviates the symptoms better and faster in patients with allergic conjunctivitis that is mild to moderate in nature.
(2) To assess the common drug-related adverse effects.
Methodology:
Our research was a Prospective, Open Label, Randomized study that took place in the Ophthalmology (OPD) department of MVJ Medical College and Research Hospital for a time period of 6 months after approval from the Institutional Ethical Committee.
There were several inclusion standards that divided the participants into 2 groups
Group 1 – Participants administering Olopatadine Hydrochloride
Group 2 – Participants administering Alcaftadine
The basic demographics, chief complaints and Total ocular symptom scores (used for comparing the efficacy) were recorded using ‘Patient Pro forma’.
Results: The study included 138 participants in total. Utilizing the Wilcoxon rank-sum test in Statistical Analysis Software version 9.2, the mean scores, standard deviation, and p values from the baseline (Day 1), Day 3, and Day 7 were calculated. The p-value on day 1 was determined to be 0.45, while the p-value on day 3 was 0.43. The outcomes on these days showed that neither of the patient's group’s responses was statistically significant. The p-value on Day 7 was considered statistically significant, with the value being 0.016. The
common adverse effects of the drugs were found to be a burning sensation, headache, dizziness, and redness.
Conclusion: Both medications were found out to be effective in treating allergic conjunctivitis, with Alcaftadine being significantly more efficacious than Olopatadine in terms of treating the allergic symptoms.
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| Keyword:
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Alcaftadine, olopatadine, efficacy, Total ocular symptom score (TOSS), allergic conjunctivitis
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2024.16.01.011
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| Download:
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