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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Uv-Spectrophotometric Method Development And Validation Of Synthesized Phenytoin

Author: TABSSUM INAMDAR, UDAYKUMAR BOLMAL, CHETAN ANAGALLI, BHAKTI RAJPUT, SHWETA CHOUGALE, NEHA KANBARKAR, ANURAG DUBEY
Abstract: Objectives: The objective of present work was to develop and standardize UV-spectrophotometric method for estimation of Phenytoin in marketed formulation. Materials and method: UV-Spectrophotometric method was developed using 1 N NaOH as solvent. The developed method was standardized in terms of validation parameters such as simple, sensitive, precise, linear, accurate, robust, reproducible as per ICH Q2(R1) guidelines. For estimation of phenytoin in marketed formulation this newly developed method was successfully applied. Results: Phenytoin exhibits ?max at 218 nm and in the Beer’s range 2 to 10 µg/ml Beer’s law was obeyed. The limit of detection was found to be 1.71µg/ml and limit of quantification was found to be 5.20 µg/ml. Recovery of Phenytoin in marketed formulation was obtained in range of 100-106%. All the precision and repeatability results were observed within the accurate range less than 2%. Conclusion: The method was found to be simple, accurate, environment friendly, reproducible and marketed formulation of Phenytoin can be estimated.
Keyword: Phenytoin, Beer’s law, 1 N NaOH, UV-spectrophotometer, Validation.
DOI: https://doi.org/10.31838/ijpr/2024.16.01.005
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