|
Formulation Development and Evaluation of Liquid self-emulsifying drug delivery system (L-SEDDS) to improve solubility and bioavailability of the poor water soluble drug Bictegravir Sodium
|
|
| Author:
|
VAIBHAV WAGH, AMIT KASABE, VISHAL PANDE
|
| Abstract:
|
The aim of the present study was to formulate, optimize and evaluate the liquid self-emulsifying drug delivery systems (L-SEDDS) of Bictegravir Sodium by use of factorial designs to enhance the oral absorption of Bictegravir Sodium by improving its solubility, dissolution rate, and diffusion profile. SEDDS are the isotropic mixtures of oil, surfactant, co-surfactant and drug that form oil in water microemulsion when introduced into the aqueous phase under gentle agitation.Solubility of Bictegravir Sodium in different oils, surfactants, and co-surfactants was determined for the screening of excipients. Formulations were developed based on the optimum excipient combinations with the help of data obtained through the maximum micro emulsion region containing combinations of oil, surfactant, and co-surfactant. The optimum formulation of L-SEDDS contains Capmul MCM (16.58 mg/ml) was selected among the screened vehicles as an oil system with the highest solubilisation potential. As surfactants, PEG 400 was used as surfactants in about 80 (13.25 mg/ml) and Polyethylene glycol (17.48 mg/ml).The L-SEDDS was evaluated for the following drug content, self-emulsification time, rheological properties, zeta potential, in vitro diffusion studies, thermodynamic stability studies, and in vitro dissolution studies. Overall, this study suggests that the dissolution and oral bioavailability of Bictegravir Sodium could be improved by L-SEDDS technology.
|
| Keyword:
|
Bictegravir Sodium, Liquid self-emulsifying drug delivery systems (L-SEDDS).
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2020.12.04.721
|
| Download:
|
Request For Article
|
|
|