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Topical Delivery Of Cape Through Microsphere Loaded Gel
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| Author:
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SUNIL KUMAR SHAH, SHIVAM TIWARI, MUKESH K. PATEL, B. K. DUBEY, DEEPAK BASEDIYA
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| Abstract:
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CAPE (caffeic acid phenethyl ester) incorporated microspheres formulate and evaluate these microspheres for topical application. In order to achieve the objective firstly various batches of CAPE loaded microspheres were
formulated using varying concentrations of ethyl cellulose as the polymeric matrix and solvent evaporation method. All the microsphere formulations were characterized for yield, entrapment efficiency, In-vitro drug release particle size and FTIR studies were also performed to confirm the non-interference of the drug and excipients. The maximum drug release of CAPE over a period of 12 h was obtained in F2 with 71.02 ± 0.64 %drug concentration found in the dissolution medium whereas the minimum release was witnessed for F5 with
56.89 ± 0.47 drug concentration. The formulation F2 was found to be the most appropriate microspheric formulation loaded with CAPE with good yield, drug encapsulation as well as in vitro drug release. It was therefore considered for formulation in the form of gel. All formulation was achieved employing 22 factorial approaches using both the polymer (carbopol 934) and polypropylene glycol at two concentration levels. All formulations loaded with F2 were found to be white and transparent with good homogeneity with pH ranging
from 4.92 to 6.1 confirming that the formulations will be compatible to the skin for topical application. On the basis of the results obtained from the study it can be concluded that Carbopol 934 1% w/v and propylene glycol 20% w/v form an excellent combination for development of gel loaded with microsphere of CAPE.
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| Keyword:
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Microspheres, CAPE, Polymeric matrix, Gel, Solvent Evaporation.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2023.15.03.004
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| Download:
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