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Model Dependent and Independent Approaches to compare In vitro Release Profiles of hydrophilic polymer Based Matrix Tablets.
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| Author:
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JALPA R. PATEL, DR. MAHAVIR CHHAJED, DARPINI S. PATEL, DR.BHAVIKA.PATEL, SANTOSH KUMAR VAIDYA
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| Abstract:
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The main objective of the present study was to compare the release profiles of hydrophilic polymer based matrix tablets of Fosinopril sodium. Dissolution studies were carried out by using United States Pharmacopoeia-XXIII type-II dissolution apparatus. The release rate was quantitatively determined by a UV method. Matrix tablets based on SFG, HPMC K15M and Acrypol 934 showed controlled release up to 14 hours. The release patterns were evaluated using model-dependent approaches (zero order, Higuchi’s, Korsmeyer’s and Weibull’s model) and model-independent approach (the similarity factor, f2). Most of the release patterns were fitted to Korsmeyer’s model with n values between 0.663 to 0.816, indicating the release mechanisms were governed by both diffusion and erosion. From the Weibull equation, the shape parameter was found to be sigmoid or S-shaped. From the value of f2 it was revealed that F4 shows similar dissolution profile to theoretically developed profile than others.
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| Keyword:
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Matrix, Fosinopril, hydrodynamic, Weibull equation, prodrug
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.719
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| Download:
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