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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Comparing the effect of Furosemide and Amlodipine on the level of some biochemical variables in male patients with Hypertension in Salah al-Din Governorate

Author: , KHALIDA KHALEEL ABDULLAH, IMAN ISMAEL KHALEEL, BAHHAR RAED TAWFEEQ
Abstract: The current study aimed to identify the therapeutic effect of Furosemide at a dose of 40 mg and to compare its effect with Amlodipine at a dose of 10 mg on some biochemical parameters of males with high blood pressure who used the two treatments daily and for a certain period of time (1 year, 2year and 3year). The biochemical parameters included estimation of the levels of the aldosterone, Angiotonsin-1 hormones, urea and creatinine. This have a look at became performed for the duration from the start of April 2022 to the cease of September 2022. The have a look at included (100) randomly decided on samples belonging to the control group and a group of male patients with Hypertension whose ages ranged from (45-75 years), where samples were collected From the health centers in (Samarra, Tikrit, Balad) and a questionnaire was organized to collect information for each person. Blood samples had been acquired from the brachial vein with a quantity of (10ml) through a clinical syringe, taking information about patients with high blood pressure who used Furosemide and Amlodipine treatment daily for a certain period of time. The outcomes of the checks confirmed a substantial increase (P=0.01) in the level of urea , creatinine angiotensin-1and aldosterone hormones When furosemide is used for a long period of time in groups 2, 3 and 4 compared with the control group and with groups 5, 6 and 7, while decrease level of urea ,creatinine angiotensin-1,and aldosterone hormones variables in groups 5, 6 and 7 when Amlodipine is used compared with control group.
Keyword: Furosemide, Amlodipine, Angiotensin, Aldosterone, Hypertension
DOI: https://doi.org/10.31838/ijpr/2023.15.02.001
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