|
Sirna- A Potential Therapy for Covid-19 Infection
|
|
| Author:
|
DEEPAK VENKATARAMAN N, PRIYA MS, MANOGNA K, PURUSHOTH PRABHU T, SHILPA R, LOGIDHASAN L
|
| Abstract:
|
Background: The deadly virus COVID- 19 has affected more than 1 crore people and claimed more than 5 lakh lives worldwide according to the World health organization. Though there are numerous treatment modalities available including anti-bacterials, antivirals, vaccines etc., none of them can be considered as effective cure for SARS CoV- 2 virus as they are mostly non-specific in action.
Aim: siRNA therapy can be considered as a significant treatment modality due to its specificity in action. The aim of this review is to explore siRNA as a potential treatment strategy for the treatment of COVID- 19.
Materials and Methods: In this review we shall explore the targets of siRNA therapy which includes viral RNA-dependent RNA polymerase, helicase, protease and nucleoprotein N. siRNA related patents provide solutions for novel RNAi techniques, high expense of chemically synthetic siRNA, techniques for restraining SARS-CoV by disturbing RNA etc., siRNA-based drug delivery systems and limitations of nanocarrier delivery system were reviewed. siRNA is a gene silencer that targets highly conserved sequences which codes for protease 3CL (nsp5) and viral helicase (from 16-18 kbp).
Conclusion: Thus, siRNA-based therapy is considered highly efficacious as it can hit the highly conserved regions of SARS-CoV-2 RNA.
|
| Keyword:
|
COVID- 19, siRNA therapy, nanocarrier drug delivery system, gene silencer, Protease, Viral helicase.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2023.15.01.017
|
| Download:
|
Request For Article
|
|
|