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A Promising Challenges In Sublingual Drug Delivery System
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| Author:
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VIKRANT NIKAM, GAURI SHAHARKAR, VIVEKANAND KASHID, POOJA CHAVAN, JYOTI KHAPARE
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| Abstract:
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The sublingual and buccal routes of administration have considerable benefits for each local and systemic drug delivery. They have proven to be an advantageous choice to the common oral route, particularly when quickly onset of action is required. Drugs can be rapidly and immediately absorbed into the systemic circulation through venous drainage to the choicest vena cava. The oral immune device includes a variety of antigen-presenting cells, together with Langerhans cells, as nicely as myeloid and plasmacytoid dendritic cells (DCs) with a distinct localization in the mucosa, alongside the lamina propria and in subepithelial tissues, respectively. In the absence of risk signals, all these DC subsets are tolerogenic in that they assist the differentiation of Th1- and IL10-producing regulatory CD4+ T cells. Oral tissues incorporate restricted numbers of mast cells and eosinophils, basically positioned in submucosal areas, thereby explaining the excellent security profile of SLIT. Resident oral Th1, Th2, and Th17 CD4+ T cells are positioned alongside the lamina propria, in all likelihood representing a defence mechanism towards infectious pathogens. Second-generation sublingual vaccines are being developed, primarily based upon recombinant allergens expressed in a native conformation, perchance formulated with Th1/T reg adjuvants and/or mucoadhesive particulate vector systems especially designed to goal oral dendritic cells.
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| Keyword:
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Sublingual drug delivery system, Dendritic cells, Buccal route, Oral mucosa
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.717
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| Download:
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