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Impact Of Predisposing Factors To Chemotherapy Induced Adverse Drug Reactions In Cancer Patients
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| Author:
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, E SUNIL KUMAR, TLN CHANDAN, LUBAINA INSTA MALLICK, G MANASA, NC MOUNIKA
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| Abstract:
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Introduction: Adverse drug reactions are the main drug related problems identified especially in the patients undergoing cancer chemotherapy. This study helps in understanding the impact of predisposing factors on occurrence of adverse drug reactions, minimizing the risk of drug induced hospital stay, ease of individualized drug therapy and enhancing health related quality of life.
Objective: This study aims to evaluate the impact of predisposing factors for chemotherapy induced hematological and renal system adverse drug reactions in cancer patients.
Material and Methodology: A hospital based prospective observational study involving in data collection from the patients and case records regarding predisposing factors and incidence of ADRs to evaluate the influence of predisposing factors by means of number and severity of ADRs occurring.
Results and Summary: This study was carried out with 112 patients who were presented with cancer and are on chemotherapy, the following observations evaluated. Patients aged more than 60 years (52%), Male Gender (48%), Low and High BMI (50% & 47%), Metastatic Cancer (65%), Frailty Index > 4 (47%), ECOG Performance Status-3 (83%) and Charlson Comorbidity Index 4-7 (50%) are more vulnerable for the incidence of ADRs when compare to remaining.
Conclusion: Predisposing factors increases the possibility of occurrence of adverse drug reactions in cancer patients. Our study reveals that the predisposing factors like age, gender, underweight, obese, metastasis, frailty greater than four, performance status two and comorbidity between four to seven had more chances of occurring ADRs in cancer patients.
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| Keyword:
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Predisposing Factors, ADRs, Chemotherapy, Frailty Index, Charlson Comorbidity Index
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2023.15.01.015
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| Download:
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