*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *       

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Immunoproteomics Physicochemical Analysis of Heterodimeric neurotoxic phospholipases A2 from Apis cerana

Author: GOMASE V.S.*, PANGARKAR P.R., KEMKAR K.R., ALBHAR K.G., KOLSURE A.K., DHAMANE S.P., POTNIS V.V.
Abstract: In proteomics and genomics investigation the in-silico approach is widely used. For peptide-based vaccine and diagnosis development, one of the important steps is T cell epitope prediction. In this investigation neurotoxin from Apis cerana is used to identify potential peptides binders. In this assay, we used algorithms of PSSM and SVM to identify potential antigenic epitope and the prediction of the binding affinity of toxin protein having 138 residues, which shows 130 nonamers. In addition, we also identified a number of the TAP-binders peptide based on amino acid sequence and its biochemical properties that have the highest affinity along with strong binding antigen peptides to major histocompatibility complex (MHC) class I & II molecules.
Keyword: peptides binders; machine learning techniques; MHC binders; TAP; PSSM
DOI: https://doi.org/10.31838/ijpr/2023.15.01.014
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