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Design And Characterization Of Amorphous Solid Drug Delivery For Enhancement Of Aqueous Solubilisation Of Cabotegravir.
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| Author:
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RAMDAS BABURAO RODE, RAKESH KUMAR MEEL
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| Abstract:
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Drugs with limited water solubility are often formulated using amorphous solid dispersion (ASD). ASDs contain polymers as essential parts, however it is unclear how polymers work to create and maintain supersaturated solutions, which improve oral absorption in vivo. By using solid dispersions and the spray drying method, the current work aimed to increase the in vitro dissolution profile and content uniformity of cabotegravir. The FDA has approved Cabotegravir, a BCS class II antiviral medication with weak water solubility, for the treatment of HIV infections. Nevertheless, Cabotegravir has a number of drawbacks, including hepatotoxicity, instability in an acidic environment, and poor oral bioavailability. Due to its limited solubility, 84% of the dosage taken orally is eliminated from the body unaltered. Spray drying was used to create the ASDs from a selection of polymers, and they were then examined for drug content uniformity, Fourier transform infrared spectroscopy, Powder X-ray diffraction (PXRD), Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Dissolution studies, and Stability studies.
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| Keyword:
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Cabotegravir, Amorphous solid dispersion (ASD)
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.04.021
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| Download:
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