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Formulation & Evaluation Of Polymer Based Microspheres Of Betahistine Hydrochloride As Sustained Release System In The Treatment Of Vertigo
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| Author:
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EKANT RATHI, SURYAKANT VERMA, JONEE PANWAR, AYUSH YADAV, SACHIN TYAGI, PRANJAL KUMAR SINGH
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| Abstract:
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The aim of the present study is to formulate and evaluate the microspheres of Betahistine Hydrochloride as sustained release system to provide the prolonged effect of the drug in the treatment of vertigo. Microspheres were prepared by the solvent evaporation technique using Chitosan as polymer and Sodium tripolyphosphate as cross-linking agent. Chitosan microspheres loaded with Betahistine Hydrochloride were prepared by solvent evaporation method. Briefly, Chitosan was dissolved in 20 ml of 1% v/v acetic acid solution and then betahistine hydrochloride (50mg) was added to this solution with continuous stirring until a uniform dispersion was obtained (Sol.-1). This solution (Sol.-1) was kept overnight to get chitosan dissolved properly. A 2mg/ml STPP solution is prepared by dissolving STPP (200 mg) in 100 ml of distilled water (Sol.-2). The microspheres were prepared by dropping the bubble free solution-1 slowly into the solution-2 through a disposable syringe (with 16 N needle on it). The solution-1 was added drop by drop into the solution-2 with continuous stirring at the rate of 450 rpm and the temperature was maintained 45° C throughout the process. The dropping rate was 20 drops/min and the falling distance was 5 cm. After the complete addition of solution-1 into the solution-2 the mixture was allowed to react for 3hrs with continuous stirring. After that the microspheres were filtered out and washed with the deionized water several times and then dried in the hot air oven for 4hrs at 50° C. The prepared microspheres exhibited prolonged drug release and remained buoyant for more than 18 hrs. It was discovered that the microspheres had a regular shape and were quite porous. The drug entrapment was found to be 71.63% to 95.67% with increasing polymer to drug ratio. All the formulations demonstrated favorable in-vitro floating characteristics. Thus, the prepared microspheres may prove to be potential candidates.
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| Keyword:
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chitosan, solvent evaporation technique, microspheres, betahistine hydrochloride.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2023.15.01.001
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