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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Current Status Of Gene Therapy For Cancer Treatment

Author: SHIV KUMAR, AMITA TILAK, DILIP KUMAR ARYA, PRASHANT PANDEY, NEHA, PS RAJINIKANTH
Abstract: Though there are many therapies which can considerably improve patient outcomes, there is still no definitive “cure” for cancer. Present cancer therapies including chemotherapy and radiation therapy have severe side effects and often prove unsuccessful at completely eradicating malignant cells. In particular gene therapy holds great potential to selectively target cancer cells, destroying the cancer while leaving a healthy tissue intact. Treatment of gene is a curative access which is planned to rectify certain defects of molecule. Suicide gene therapy, anti-angiogenic gene therapy, immunotherapy and oncolytic virotherapy are some of the gene therapeutic approaches used to treat cancer. The problem in gene therapy is to deliver adequate genetic material into target cells while also maintaining gene expression for the desired amount of time. Various methods of delivery can be used to introduce genetic material to their target tissues or cells including viral and non-viral methods.; and physical method. The combination of gene therapy with conventional approach, upgrade the remedial adequacy. In recent years, the development of gene therapy systems as new treatment or prevention strategies for cancer has been explored.
Keyword: Cancer, Gene therapy, suicide gene therapy, anti-angiogenic gene therapy, RNAi strategies, viral, nonviral.
DOI: https://doi.org/10.31838/ijpr/2022.14.04.010
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