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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Preparation And Evaluation Of Polyherbal Cream Of The Combined Extract Of Aegle Marmelos, Acalypha Indica And Tridax Procumbens For The Treatment Of Skin Diseases

Author: PURUSHOTH PRABHU T, SURESH R, PARTHASARATHI P, DEEPAK VENKATARAMAN N, RAVICHANDRAN S, KABILAN.N, MANIKANDAN.E.M, PRIYA MS, PAVITHRA BHARATHY, SARANYA B
Abstract: Antimicrobial resistance and Side effect of steroids was major concern on Topical preparation for skin disease and infection like eczema, impetigo skin damage etc. Conventionally many natural plants have good antimicrobial and wound healing activity. Various research shows that Tridax procumbens Aegle marmelos and Acalypha Indica show good antibacterial, anti-inflammatory and wound healing activity. Our aim was to prepare and evaluate the polyherbal formulation of three plants and screened for antibacterial activity. The methanol extract of Tridax procumbens and Acalypha indica and Aegle marmelos studied for antibacterial activity against the bacteria causing infections and increased incidence of resistance against Bacillus subtilis and Staphylococcus aureus. Based on results extracts are formulated in to cream with suitable base for skin infections. The combined extract was optimized with base and formulated herbal cream. The formulated cream was evaluated with all parameters such as colour, spreadability, irritancy, microbial growth, odour, homogenity, pH, washability, texture. Antibacterial activity was done by disc diffusion assay and formulated cream of different concentration was compared with standard drug streptomycin. The zone of inhibition of Bacillus substilis and Staphylococcus aureus. was found to be 12 and 10 mm with respect to higher concentration of formulation drug and was comparable with standard drug streptomycin. Our cream formulation shows good diffusion properties which was evidenced by antibacterial activity of cream formulation with similar effect given by extracts. This cream formulation offers good antimicrobial, anti-inflammatory and wound healing activity and effective treatment and alternative for steroid preparation and also effective for resistant organism in skin infections.
Keyword: Tridax procumbens Aegle marmelos, Acalypha Indica, Bacillus substilis, Staphylococcus aureus
DOI: https://doi.org/10.31838/ijpr/2022.14.04.008
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