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Influence Of Natural Extract of Strychnos Nux Vomica on Cutaneous Wound Healing in Albino Rats in Incision Wound Model
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| Author:
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BHUNESHWAR DUTTA TRIPATHI, NITU SINGH, NEETESH KUMAR JAIN
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| Abstract:
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Aim- The aim of the present investigation is to evaluate influence of natural extract of strychnos nux vomica on cutaneous wound healing in albino rats in incision wound model.
Material & Methods- The seeds of Strychnos nux-vomica were purchased from authorized herbal supplier in local city market. The seeds of Strychnos nux-vomica were dried under shade for 15 days. The dried seeds were grinded under mechanical grinder machine to prepare cores powder, for extractions. The acute dermal toxicity study was carried out in adult female albino rats by “fix dose” method of OECD (Organization for Economic Co-operation and Development) Guideline No.434. The dried extracts and fractions (10 % w/w) of the dried seeds of Strychnos nux-vomica was triturated in pestle mortar with steric acid ointment base. And used further in excision cutaneous wound healing model in animals.
Results- In Incision wound model among the extract treated rats ethanolic extract of S. nux-vomica treated rats showed highest tensile strength 311.4 gm/mm2 during examination of wound breaking as compared to animals of normal (241.5 gm/mm2) control groups. While in other extract treated groups except petroleum ether treated rats, chloroform, Methanol and acetone extract treated rats showed more wound breaking strength 268.4, 254.4 and 218.9 gm/mm2 respectively. In dead space wound model as per Table No. 4.5; the ethanolic extract treated rats exhibited higher weight of wet (337.3 mg) and dry (102.5 mg) granulation tissue as compared to weight of wet (233.2 mg) and dry (64.83 mg) granulation tissue in rats of normal control group. Conclusion- In incision wound model all extracts were administered orally at a dose of 100 mg/kg body weight for 14 days. At the end of study tensile strength (Skin breaking strength) was measured with the help of tensiometer. Among all extracts ethanolic extract of seeds of Strychnos nux-vomica were found to be most effective in management of delayed wound healing.
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| Keyword:
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Natural Extract, Strychnos Nux Vomica, Cutaneous Wound Healing, Albino Rats, Incision Wound Model.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.04.016
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| Download:
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