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Accelerated Stability Test for Wound Ointment Combination of Snakehead Fish Extract and Golden Sea Cucumber with Variations of Gelling Agent Carbopol 940 and CMC-Na
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| Author:
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MOHAMAD ANDRIE, WINTARI TAURINA
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| Abstract:
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An ointment combination of snakehead fish extract and kelulut honey has the effect of accelerating the wound healing process. The addition of golden sea cucumber extract, betel extract, and clove oil to the formula can increase the effectiveness of the ointment in the wound healing process, but in the orientation study, the addition of gold sea cucumber extract, betel extract, and clove oil can reduce the consistency of the ointment preparation so it is feared that it will affect the stability of the ointment. The addition of Carbopol 940 and CMC-Na as gelling agents can increase the consistency of the preparation and maintain the stability of the ointment preparation. The purpose of this study to determine the optimum concentration of Carbopol 940 and CMC-Na which can maintain the stability of the ointment preparation physically, chemically, and microbiologically during 28-day shelf life at a temperature and humidity of 40? ± 2?/RH 75% ± 5%). Variations in the concentration of Carbopol used were 1% and 2%, and CMC-Na 2% and 3%. The results of the physical stability test showed that F1 ointment had the best criteria for physical properties, but F2 had the best stability compared to other ointments. The F1 and F2 ointment formulas were unstable in the chemical stability test but met the requirements for the microbiological stability test.
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| Keyword:
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Snakehead fish extract (Channa striata), Golden sea cucumber extract (Stichopus hermanii), ointment, Carbopol 940, CMC-Na
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2022.14.03.019
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| Download:
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